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Gene Expression Data
Assay Details
Assay
Reference: J:237224 Kim JY, et al., Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol. 2016 Nov 15;419(2):336-347
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7437606
Gene symbol: Tubb3
Gene name: tubulin, beta 3 class III
Antibody: anti-Tubb3 (PRB-435P)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4J: embryonic day 16.5; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: green - Tubb3; red - Pax6 (assay MGI:7437604).
Structure Cell Type Level Pattern Image Note
TS24: neural retina amacrine cell Present 4J
TS24: neural retina retinal ganglion cell Present 4J
TS24: retina layer Present Regionally restricted 4J Expressed in post-mitotic migrating cells in outer neuroblastic layer.
TS24: pigmented retinal epithelium Absent 4J
Specimen 4K: embryonic day 16.5; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: green - Tubb3; red - Pax6 (assay MGI:7437604).
Structure Cell Type Level Pattern Image Note
TS24: pigmented retinal epithelium Present Regionally restricted 4K Ectopic expression at the basal side of the newly formed abnormal multi-cell layered region.
TS24: neural retina amacrine cell Present 4K
TS24: neural retina retinal ganglion cell Present 4K
TS24: retina layer Present Regionally restricted 4K Expressed in post-mitotic migrating cells in outer neuroblastic layer.
Specimen 4L: embryonic day 16.5; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: green - Tubb3; red - Pax2 (assay MGI:7437605).
Structure Cell Type Level Pattern Image Note
TS24: retina layer amacrine cell Present 4L
TS24: retina layer retinal ganglion cell Present 4L
Specimen 4M: embryonic day 16.5; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: green - Tubb3; red - Pax2 (assay MGI:7437605).
Structure Cell Type Level Pattern Image Note
TS24: neural retina amacrine cell Present 4M
TS24: neural retina retinal ganglion cell Present 4M
TS24: pigmented retinal epithelium Present Regionally restricted 4M Ectopic expression was seen in the abnormal multi-cell layered region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory