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Gene Expression Data
Assay Details
Assay
Reference: J:292175 Asselin L, et al., Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity. Nat Commun. 2020 May 15;11(1):2441
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7434979
Gene symbol: Kif21b
Gene name: kinesin family member 21B
Antibody: Anti-Kif21b (HPA027274)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 2c: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex cerebral cortex neuron Present Regionally restricted 2c Restricted expression was detected in postmitotic compartments of the neuronal epithelium with a particularly intense signal in the axon-rich zone.
Specimen 2d: embryonic day 14.5 (more )
Note: Double labeled: magenta - Kif21b; green - Tubb3 (assay MGI:7434980).
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex cerebral cortex neuron Present Regionally restricted 2d Merge , 2d Kif21b Expression was detected exclusively in postmitotic neurons.
Specimen S2b E12.5: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex cerebral cortex neuron Present Regionally restricted S2b E12.5 Restricted expression was detected in postmitotic compartments of the neuronal epithelium with a particularly intense signal in the axon-rich zone.
Specimen S2b E16.5: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: cerebral cortex cerebral cortex neuron Present Regionally restricted S2b E16.5 Restricted expression was detected in postmitotic compartments of the neuronal epithelium with a particularly intense signal in the axon-rich zone.
Specimen S2b E18.5: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted S2b E18.5 Restricted expression was detected in postmitotic compartments of the neuronal epithelium with a particularly intense signal in the axon-rich zone.
Specimen S2c E12.5 left: embryonic day 12.5 (more )
Note: Double labeled: magenta - Kif21b; green - Tubb3 (assay MGI:7434980).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex cerebral cortex neuron Present Regionally restricted S2c E12.5 Merge left , S2c E12.5 Kif21b left Expression was detected exclusively in postmitotic neurons.
Specimen S2c E12.5 right: embryonic day 12.5 (more )
Note: Double labeled: magenta - Kif21b; gray - Eomes (assay MGI:7434993).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex cerebral cortex neuron Present Regionally restricted S2c E12.5 Merge right , S2c E12.5 Kif21b right Expression was detected exclusively in postmitotic neurons.
Specimen S2c E18.5 left: embryonic day 18.5 (more )
Note: Double labeled: magenta - Kif21b; green - Tubb3 (assay MGI:7434980).
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted S2c E18.5 Merge left , S2c E18.5 Kif21b left Expression was detected exclusively in postmitotic neurons.
Specimen S2c E18.5 right: embryonic day 18.5 (more )
Note: Double labeled: magenta - Kif21b; gray - Eomes (assay MGI:7434993).
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted S2c E18.5 Merge right , S2c E18.5 Kif21b right Expression was detected exclusively in postmitotic neurons.
Specimen S2e WT: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: brain Present S2e WT
Specimen S2e KO: postnatal day 0; Kif21btm1a(KOMP)Wtsi/Kif21btm1a(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS27: brain Absent S2e KO
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory