Tg(CASP4)1Bux
Transgene Detail
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| Symbol: |
Tg(CASP4)1Bux |
| Name: |
transgene insertion 1, Joseph Buxbaum |
| MGI ID: |
MGI:7433250 |
| Transgene: |
Tg(CASP4)1Bux Location: unknown
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| Alliance: |
Tg(CASP4)1Bux page
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| Strain of Origin: |
C57BL/6 x C3
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CASP4)1Bux expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CASP4 (837) |
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Mutation details: The human CASP4 transgenic construct contains the entire human CASP4 gene and 6.8 kb of upstream sequences including the promoter region (bacterial artificial chromosome clone, RP11 693N9). The BAC clone also includes the long isoform of CASP12 (carrying a single nucleotide variant found in a small proportion of humans with African ancestry). The long isoform is catalytically inactive but acts to suppress LPS-induced cytokine secretion and NFKB activation.
(J:256722)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:256722 Kajiwara Y, et al., A critical role for human caspase-4 in endotoxin sensitivity. J Immunol. 2014 Jul 1;193(1):335-43 |
| All: |
6 reference(s) |
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Analysis Tools
