Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(CDX2-cre/ERT2)741Erf
Name:	transgene insertion 741, Eric Fearon
MGI ID:	MGI:7433054
Synonyms:	CDX2-creERT2
Transgene:	Tg(CDX2-cre/ERT2)741Erf  Location: unknown
Alliance:	Tg(CDX2-cre/ERT2)741Erf page

Strain of Origin:

C57BL/6J x SJL/J

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(CDX2-cre/ERT2)741Erf expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human CDX2 (1045) Cdx2  (MGI:88361)   Mutation details: The transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain), and a bovine growth hormone polyadenylation cassette. Compared to the CDX2P-CreER T2 transgenic line #752, transgenic line #741 shows increased tamoxifen-regulated Cre function in distal colon epithelium. (J:199069)

Activity:	Tissue activity of this recombinase allele
Driver:	CDX2 (human) Summary of all recombinase alleles driven by CDX2. Alliance human CDX2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:199069 Feng Y, et al., Sox9 induction, ectopic paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic apc inactivation. Am J Pathol. 2013 Aug;183(2):493-503
All:	4 reference(s)