Tg(APOE-rtTA,tetO-cre)1515-3Reh
Transgene Detail
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| Symbol: |
Tg(APOE-rtTA,tetO-cre)1515-3Reh |
| Name: |
transgene insertion 1515-3, Robert E Hammer |
| MGI ID: |
MGI:7432912 |
| Synonyms: |
ApoE-rtTA:TRE2-Cre |
| Transgene: |
Tg(APOE-rtTA,tetO-cre)1515-3Reh Location: unknown
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| Alliance: |
Tg(APOE-rtTA,tetO-cre)1515-3Reh page
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| Strain of Origin: |
(C57BL/6 x SJL/J)F2
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| Transgene Type: |
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Transgenic (Inducible, Recombinase, Transactivator) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Tg(APOE-rtTA,tetO-cre)1515-3Reh expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| bacteria |
tetO |
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Mutation details: The transgenic construct is designed to have the promoter, intron 1 and hepatic control region (HCR) of the human apolipoprotein E gene driving expression of the reverse tetracycline-controlled transactivator (rtTA*M2) promoter element. The 2.8kb TRE-Cre transgenic construct is designed to have Cre recombinase under the control of tetO (tet-responsive element; TRE2). These constructs were coinjected into one-cell B6SJLF2 embryos. Both transgenes integrated at the same site in founder line 1515-3 mice.
(J:332969)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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tetO
(bacteria)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:332969 Comerford SA, et al., Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent. PLoS Genet. 2023 Jan;19(1):e1010595 |
| All: |
1 reference(s) |
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Analysis Tools
