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Gene Expression Data
Assay Details
Assay
Reference: J:75868 Lu QR, et al., Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 5;109(1):75-86
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7432600
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti PAX6 (DSHB)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5C +/+ E10.5: embryonic day 10.5 (more )
Note: Double labeled: green - Pax6; red - Nkx2-2 (assay MGI:7432601).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Strong Regionally restricted 5C +/+ left Expressed in the p2 domain (gives rise to V2 interneurons), which was dorsal to the motor neuron progenitor domain (low Pax6 expression).
Specimen 5C -/- E10.5: embryonic day 10.5; Olig2tm1Rth/Olig2tm1Rth (more )
Note: Double labeled: green - Pax6; red - Nkx2-2 (assay MGI:7432601).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Strong Regionally restricted 5C -/- left Ventralization of the expression to abut the Nkx2-2-expressing progenitors was seen compared with the wild-type.
Specimen 5C +/+ E12.5: embryonic day 12.5 (more )
Note: Double labeled: green - Pax6; red - Nkx2-2 (assay MGI:7432601).
Structure Level Pattern Image Note
TS20: spinal cord lateral wall Present Regionally restricted 5C +/+ middle Expressed in the p2 domain (gives rise to V2 interneurons), which was dorsal to the motor neuron progenitor domain (low Pax6 expression).
Specimen 5C -/- E12.5: embryonic day 12.5; Olig2tm1Rth/Olig2tm1Rth (more )
Note: Double labeled: green - Pax6; red - Nkx2-2 (assay MGI:7432601).
Structure Level Pattern Image Note
TS20: spinal cord lateral wall Strong 5C -/- middle Ventralization of the expression to abut the Nkx2-2-expressing progenitors was seen compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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