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Gene Expression Data
Assay Details
Assay
Reference: J:265083 Mullen RD, et al., Osterix functions downstream of anti-Mullerian hormone signaling to regulate Mullerian duct regression. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8382-8387
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7431531
Gene symbol: Sp7
Gene name: Sp7 transcription factor 7
Reporter: lacZ
Direct Detection
Results
Specimen 3A: embryonic day 13.75; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS21: female reproductive system Absent 3A No expression in female reproductive tract from E13.75 to E17.5.
Specimen 3B: embryonic day 14.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS22: female reproductive system Absent 3B No expression in female reproductive tract from E13.75 to E17.5.
Specimen 3C: embryonic day 15.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS23: female reproductive system Absent 3C No expression in female reproductive tract from E13.75 to E17.5.
Specimen 3D: embryonic day 16.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS24: female reproductive system Absent 3D No expression in female reproductive tract from E13.75 to E17.5.
Specimen 3E: embryonic day 17.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS25: female reproductive system Absent 3E No expression in female reproductive tract from E13.75 to E17.5.
Specimen 3F: embryonic day 13.75; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS21: paramesonephric duct of male Present Regionally restricted 3F Expression in male Mullerian duct mesenchyme beginning at E13.75.
Specimen 3G: embryonic day 14.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS22: paramesonephric duct of male Strong Regionally restricted 3G By E14.5, robust expression in mesenchyme throughout length of Mullerian duct.
Specimen 3H: embryonic day 15.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS23: paramesonephric duct of male Present Regionally restricted 3H Expression in Mullerian duct mesenchyme lost as duct regresses.
Specimen 3I: embryonic day 16.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS24: male reproductive system Weak Regionally restricted 3I Expression in Mullerian duct mesenchyme lost as duct regresses.
Specimen 3J: embryonic day 17.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS25: male reproductive system Ambiguous 3J Expression in Mullerian duct mesenchyme lost as duct regresses.
Specimen 4C: embryonic day 14.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS22: female reproductive system Absent 4C No expression in females.
Specimen 4E: embryonic day 14.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS22: female reproductive system Absent 4E No expression in females.
Specimen 6A: embryonic day 15.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS23: paramesonephric duct of male Present Regionally restricted 6A Expression in intact Mullerian duct.
Specimen 6B: embryonic day 16.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS24: male reproductive system Present Regionally restricted 6B Expression in Mullerian duct remnant with large gaps.
Specimen 6C: embryonic day 17.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS25: male reproductive system Present Regionally restricted 6C
Specimen 6D: embryonic day 18.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS26: male reproductive system Present Regionally restricted 6D
Specimen 6E: embryonic day 15.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS23: paramesonephric duct of male Present Regionally restricted 6E Expression in intact Mullerian duct appears thicker than in Osx Z/+.
Specimen 6F: embryonic day 16.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS24: male reproductive system Present Regionally restricted 6F Expression in longer lengths of Mullerian duct remnant with fewer gaps than in Osx Z/+.
Specimen 6G: embryonic day 17.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS25: male reproductive system Present Regionally restricted 6G Expression in longer lengths of Mullerian duct remnant near testis compared to Osx Z/+.
Specimen 6H: embryonic day 18.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS26: male reproductive system Present Regionally restricted 6H Expression similar to that of Osx Z/+. Authors report normal pattern of regression.
Specimen S4 E14.5 Osx Z/+: embryonic day 14.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS22: paramesonephric duct of male Present Regionally restricted S4_E14.5 Z/+ Expression in Mullerian duct mesenchyme
Specimen S4 E14.5 Osx Z/Z: embryonic day 14.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS22: paramesonephric duct of male Present Regionally restricted S4_E14.5 Z/Z Expression in Mullerian duct expanded compared to Osx Z/+. Expressing regions include epithelium as well as mesenchyme.
Specimen S4 E15.5 Osx Z/+: embryonic day 15.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS23: paramesonephric duct of male Present Regionally restricted S4_E15.5 Z/+ Expression in Mullerian duct mesenchyme
Specimen S4 E15.5 Osx Z/Z: embryonic day 15.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS23: paramesonephric duct of male Present Regionally restricted S4_E15.5 Z/Z Expression in Mullerian duct expanded compared to Osx Z/+. Expressing regions include epithelium as well as mesenchyme.
Specimen S4 E16.5 MDE intact Osx Z/+: embryonic day 16.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS24: male reproductive system Present Regionally restricted S4_MDE intact Z/+ Expression in Mullerian duct regions including structured epithelial cells as well as mesenchyme.
Specimen S4 E16.5 MDE intact Osx Z/Z: embryonic day 16.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS24: male reproductive system Present Regionally restricted S4_MDE intact Z/Z Expression in Mullerian duct regions including structured epithelial cells as well as mesenchyme.
Specimen S4 E16.5 MDE regressed Osx Z/+: embryonic day 16.5; Sp7tm1Crm/Sp7+ (more )
Structure Level Pattern Image Note
TS24: male reproductive system Present Regionally restricted S4_MDE regressed Z/+ Expression in Mullerian duct regions lacking structured epithelial cells.
Specimen S4 E16.5 MDE regressed Osx Z/Z: embryonic day 16.5; Sp7tm1Crm/Sp7tm1Crm (more )
Structure Level Pattern Image Note
TS24: male reproductive system Present Regionally restricted S4_MDE regressed Z/Z Expression in Mullerian duct regions lacking structured epithelial cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory