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Gene Expression Data
Assay Details
Assay
Reference: J:195652 Manso AM, et al., Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 8;288(6):4252-64
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7431102
Gene symbol: Tln2
Gene name: talin 2
Antibody: anti-Tln2 (68E7)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1B Tln2: embryonic day 9.0 (more )
Note: Double labeled: green - Tln2; red - Ttn (assay MGI:7431103).
Structure Cell Type Level Pattern Image Note
TS14: cardiac muscle tissue cardiac muscle cell Present 1B Tln2+Titin , 1B Tln2 , 1B Tln2+Titin (inset) Expression in cardiomyocytes, co-localized with Ttn expression.
Specimen 1C Tln2: embryonic day 10.0 (more )
Note: Double labeled: green - Tln2; red - Pecam1 (assay MGI:7431104).
Structure Cell Type Level Pattern Image Note
TS16: heart cardiac endothelial cell Absent 1C Tln2+PECAM , 1C Tln2
Specimen 2Bb,c: postnatal adult (more )
Note: Double labeled: green - Tln2; red - Dys (Dmd assay MGI:7431105).
Structure Cell Type Level Pattern Image Note
TS28: cardiac muscle tissue cardiac muscle cell Strong Regionally restricted 2Bb , 2Bc Strong expression in at cardiomyocyte membrane, co-localized with Dmd. Expression also in intercalated discs.
Specimen 2Be,f: postnatal adult (more )
Note: Double labeled: green - Tln2; red - Pecam1 (assay MGI:7431104).
Structure Cell Type Level Pattern Image Note
TS28: heart cardiac endothelial cell Absent 2Be , 2Bf
Specimen 2C (left): postnatal adult (more )
Note: Double labeled: green - Tln2; red - Ttn (assay MGI:7431103).
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present Regionally restricted 2C (left inset) , 2C (left) Expression not co-localized with Ttn in sarcomeres.
Specimen 2C (right): postnatal adult (more )
Note: Double labeled: green - Tln2; red - beta1D (Itgb1 assay MGI:7431106).
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present Regionally restricted 2C (right) , 2C (right inset) Expression co-localized with Itgb1 in costamere at sarcolemmal membrane.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory