Tg(Igkv3-5*-MYC)11Plbe
Transgene Detail
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| Symbol: |
Tg(Igkv3-5*-MYC)11Plbe |
| Name: |
transgene insertion 11, P Leif Bergsagel |
| MGI ID: |
MGI:7430707 |
| Synonyms: |
Vk*MYC |
| Transgene: |
Tg(Igkv3-5*-MYC)11Plbe Location: unknown Genetic Position: Chr11, Syntenic
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| Alliance: |
Tg(Igkv3-5*-MYC)11Plbe page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Igkv3-5*-MYC)11Plbe involves 1 genes/genome features (Adcy1)
View all
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Tg(Igkv3-5*-MYC)11Plbe expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MYC (4609) |
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Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector MN894515). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. Lines 11 and 24 (20 and 8 copies of the transgene, respectively, inserted chr11:6965780-7030487 with translocation of chr 7:68557535-68718226 sequence and chr17:91535994-91546658, mm39, respectively) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:131912)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:131912 Chesi M, et al., AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008 Feb;13(2):167-80 |
| All: |
2 reference(s) |
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Analysis Tools
