Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:319706
Silachev D, et al., Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation. Acta Neuropathol Commun. 2022 Jan 28;10(1):9
|
|
Assay type:
|
Immunohistochemistry
|
|
MGI Accession ID:
|
MGI:7425418
|
|
Gene symbol:
|
Pou3f2
|
|
Gene name:
|
POU domain, class 3, transcription factor 2
|
|
|
Results
|
Specimen
S4A +/+:
embryonic day 18.5
(more  )
Specimen
S4A +/+:
(close  )
|
Genetic Background:
|
involves: C57BL/6J
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
S4A C215Y/+:
embryonic day 18.5; Gnao1em2Katv/Gnao1 +
(more )
Specimen
S4A C215Y/+:
(close )
|
Genetic Background:
|
involves: C57BL/6J
|
|
Mutant Allele(s):
|
Gnao1em2Katv/Gnao1+
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
S4A C215Y/C215Y:
(close )
|
Genetic Background:
|
involves: C57BL/6J
|
|
Mutant Allele(s):
|
Gnao1em2Katv/Gnao1em2Katv
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS26: frontal cortex |
cerebral cortex neuron |
Present |
Regionally restricted |
S4A C215Y/C215Y Merged
,
S4A C215Y/C215Y Brn2
|
A decrease in immunopositive cells in layers II-V in the motor cortex was statistically significant for the homozygous mutant compared with wild type.
|
|
Analysis Tools