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Gene Expression Data
Assay Details
Assay
Reference: J:332131 Perera SN, et al., Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
Assay type: RNA in situ
MGI Accession ID: MGI:7424906
Gene symbol: Ptn
Gene name: pleiotrophin
Probe: Ptn cDNA3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2 - Ptn: embryonic day 16.5 (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Schwann cells and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS24: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Present Non-Uniform 2g , 2h The inner ONL-OECs show stronger expression than the outer ones.
TS24: olfactory nerve olfactory ensheathing cell Present 2g , 2i The mucosal OECs show expression.
TS24: trigeminal nerve Schwann cell Absent 2j , 2g The Schwann cells lack expression.
TS24: head mesenchyme Strong Regionally restricted 2i , 2h , 2j , 2g Expression is seen in a thin layer of mesenchyme surrounding the ONL and olfactory nerve fascicles and in mesenchyme surrounding trigeminal nerve fascicles.
TS24: olfactory epithelium Weak Scattered 2g , 2i
Specimen S6 - E11.5: embryonic day 11.5 (more )
Note: Parasagittal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Schwann cells and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS20: olfactory nerve olfactory ensheathing cell Present S6G , S6H The mucosal OECs show expression.
TS20: olfactory epithelium Present Widespread S6G , S6H Expressing cells are likely to include olfactory receptor neurons.
TS20: head mesenchyme Absent S6G , S6H The olfactory mucosal mesenchyme lacks expression.
Specimen S6 - E13 - I1: embryonic day 13.0 (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Schwann cells and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS21: main olfactory bulb layer olfactory ensheathing cell Present S6I1 , S6J1 The olfactory nerve layer OECs show expression.
Specimen S6 - E13 - I2: embryonic day 13.0 (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Schwann cells and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS21: olfactory nerve olfactory ensheathing cell Present S6J2 , S6I2 The mucosal OECs show expression.
TS21: head mesenchyme Strong Regionally restricted S6I2 , S6J2 Strong expression is seen in the olfactory mucosal mesenchyme. No expression is seen in the mesenchyme surrounding the olfactory nerve layer.
TS21: olfactory epithelium Present S6J2 , S6I2 Expressing cells are likely to include olfactory receptor neurons.
Specimen 12g: embryonic day 16.5 (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS24: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Present Non-Uniform 12g , 12g1 The inner ONL-OECs show stronger expression than the outer ones.
Specimen 12h: embryonic day 16.5; Ptprz1tm1Mno/Ptprz1tm1Mno (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS24: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Present Non-Uniform 12h1 , 12h The inner ONL-OECs show stronger expression than the outer ones. Expression levels in the mutant are higher than those seen in wild type.
Specimen 12i: embryonic day 16.5 (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS24: olfactory nerve olfactory ensheathing cell Present 12i , 12i1 The mucosal OECs show expression.
Specimen 12j: embryonic day 16.5; Ptprz1tm1Mno/Ptprz1tm1Mno (more )
Note: Coronal section. Immunostained with Sox10 (green) to label olfactory entheathing cells (OECs) and Tubb3 (magenta) to identify axons.
Structure Cell Type Level Pattern Image Note
TS24: olfactory nerve olfactory ensheathing cell Present 12j1 , 12j The mucosal OECs show expression. Expression levels in the mutant are higher than those seen in wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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