Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Foxp3tm1.1(flpo)Daav
Name:	forkhead box P3; targeted mutation 1.1, Dario AA Vignali
MGI ID:	MGI:7414284
Synonyms:	Foxp3Ametrine-FlpO
Gene:	Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Alliance:	Foxp3tm1.1(flpo)Daav page

Germline Transmission:	Earliest citation of germline transmission: J:312516
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Foxp3tm1.1(flpo)Daav expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Foxp3 (MGI:1891436)   Mutation details: An Ametrine-2A and FlpO (a codon-optimized flippase) cDNS followed by a 2A peptide linker was inserted after the ATG start codon of the Foxp3 gene with a AttB-Neo-AttP cassette. Germline mice were then crossed with Rosa.PhiC31 mice to remove the Neo cassette. (J:312516)

Activity:	Tissue activity of this recombinase allele
Driver:	Foxp3 (mouse) Summary of all recombinase alleles driven by Foxp3. Alliance mouse Foxp3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:	55 strains or lines available

Original:	J:312516 Andrews LP, et al., A Cre-driven allele-conditioning line to interrogate CD4(+) conventional T cells. Immunity. 2021 Oct 12;54(10):2209-2217.e6
All:	2 reference(s)