Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav
Name:	transgene insertion 13, Dario AA Vignali
MGI ID:	MGI:7414283
Synonyms:	ThPOKF/F.iCreERT2.hCD2
Transgene:	Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav  Location: unknown  Genetic Position: Chr13, Syntenic
Alliance:	Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Conditional ready, Epitope tag, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Zbtb7b/CD4-icre/ERT2,-CD2)13Daav expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Zbtb7b (MGI:102755)   Mutation details: A 562base pair fragment of the Zbtb7b silencer sequence was inserted into a mini-transgene containing the minimal Cd4 enhancer-promoter-FRT-icre/ERT2. A FRT site was inserted 1086bp upstream of the ATG codon of the icre/ERT2. The sequence encoding an internal ribosomal entry site and human CD2 were also inserted downstream of the cDNA cassette encoding icre/ERT2 and additional FRT site was inseted after the STOP codon of the CD2. The transgene expresses Cre specifically in the CD4 lineage. Founder information was not available. Line number 13 was assigned for the transgene inserted into chromosome 13 at approximately 13D1. (J:312516)

Activity:	Tissue activity of this recombinase allele
Driver:	Zbtb7b (mouse) Summary of all recombinase alleles driven by Zbtb7b. Alliance mouse Zbtb7b gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:312516 Andrews LP, et al., A Cre-driven allele-conditioning line to interrogate CD4(+) conventional T cells. Immunity. 2021 Oct 12;54(10):2209-2217.e6
All:	1 reference(s)