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Siglecfem1Yliu
Endonuclease-mediated Allele Detail
Summary
Symbol: Siglecfem1Yliu
Name: sialic acid binding Ig-like lectin F; endonuclease-mediated mutation 1, Yang Liu
MGI ID: MGI:7413916
Gene: Siglecf  Location: Chr7:43000765-43008955 bp, + strand  Genetic Position: Chr7, 28.25 cM, cytoband B3
Alliance: Siglecfem1Yliu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Insertion
    CRISPR-targeting inserted one bp (p.Glu32GlyfsTer72). (J:330795)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Siglecf Mutation:  55 strains or lines available
Notes
This allele was generated in zygotes along with Cd33em2Yliu.
References
Original:  J:330795 Wang X, et al., CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab. 2022 Aug 2;34(8):1088-1103.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory