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Siglechem2Yliu
Endonuclease-mediated Allele Detail
Summary
Symbol: Siglechem2Yliu
Name: sialic acid binding Ig-like lectin H; endonuclease-mediated mutation 2, Yang Liu
MGI ID: MGI:7413914
Gene: Siglech  Location: Chr7:55417926-55428673 bp, + strand  Genetic Position: Chr7, 33.42 cM
Alliance: Siglechem2Yliu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    CRISPR-targeting deleted 6 bp and inserted 2 bp (p.Cys53ProfsTer59). (J:330795)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Siglech Mutation:  24 strains or lines available
Notes
This allele was generated in the same zygotes as Cd22em2Yliu.
References
Original:  J:330795 Wang X, et al., CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab. 2022 Aug 2;34(8):1088-1103.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory