About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:144146 Roebroek AJ, et al., Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol Cell Biol. 2006 Jan;26(2):605-16
Assay type: Western blot
MGI Accession ID: MGI:7411149
Gene symbol: Lrp1
Gene name: low density lipoprotein receptor-related protein 1
Antibody: anti-LRP1
Assay notes: 4 to 12% NuPage gel
Results Image: 2D
 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified (a) Genetic BackgroundMutant Allele(s)Sex
LRP-WT liver E18.5 TS26: liver Present involves: 129P2/OlaHsd Not Specified
LRP-WT brain E18.5 TS26: brain Strong (b) involves: 129P2/OlaHsd Not Specified
LRP1-NPXY1-mut liver E18.5 TS26: liver Present (c) involves: 129P2/OlaHsd * C57BL/6 Lrp1tm3Ajmr/Lrp1tm3AjmrNot Specified
LRP1-NPXY1-mut brain E18.5 TS26: brain Strong (d) involves: 129P2/OlaHsd * C57BL/6 Lrp1tm3Ajmr/Lrp1tm3AjmrNot Specified
LRP1-NPXY1-mut liver E18.5 TS26: liver Present (c) involves: 129P2/OlaHsd * C57BL/6 Lrp1tm3Ajmr/Lrp1tm3AjmrNot Specified
LRP1-NPXY1-mut brain E18.5 TS26: brain Strong (d) involves: 129P2/OlaHsd * C57BL/6 Lrp1tm3Ajmr/Lrp1tm3AjmrNot Specified
LRP1-NPXY1-mut liver E18.5 TS26: liver Present (c) involves: 129P2/OlaHsd * C57BL/6 Lrp1tm3Ajmr/Lrp1tm3AjmrNot Specified
LRP1-NPXY1-mut brain E18.5 TS26: brain Strong (d) involves: 129P2/OlaHsd * C57BL/6 Lrp1tm3Ajmr/Lrp1tm3AjmrNot Specified
Notes:
(a) beta subunit
(b) Relative expression in brain higher than in liver in both wild-type and mutant embryos.
(c) Slightly lower expression in liver compared to wild type. Maturation in subunits not affected by mutation.
(d) Relative expression in brain higher than in liver in both wild-type and mutant embryos. Expression levels similar to wild type. Maturation in subunits not affected by mutation.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory