Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(KRT14-HPV16E6,HPV16E7)14Kshs
Name:	transgene insertion 14, Hans Schreiber
MGI ID:	MGI:7397259
Synonyms:	E6/E7LSL
Transgene:	Tg(KRT14-HPV16E6,HPV16E7)14Kshs  Location: unknown  Genetic Position: ChrUN, Syntenic
Alliance:	Tg(KRT14-HPV16E6,HPV16E7)14Kshs page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Mutation details: The transgenic construct contains the human KRT14 promoter/enhnacer directing expression of a beta globin intron and a loxP-flanked EGFP/STOP, and the E6 and E7 early genes from Human papilloma virus followed by a KRT14 polyA signal. It is estimated that there are about 18 copies of the transgene per homozyous cell. This allele is founder #14. (J:299115)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:299115 Bottinger P, et al., Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. Carcinogenesis. 2020 Nov 13;41(11):1605-1615
All:	1 reference(s)