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Gene Expression Data
Assay Details
Assay
Reference: J:269548 Ramirez DM, et al., Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J Comp Neurol. 2008 Apr 10;507(5):1676-93
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7388178
Gene symbol: Cyp46a1
Gene name: cytochrome P450, family 46, subfamily a, polypeptide 1
Antibody: 1F11
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 10C: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Strong 10C
TS28: retina inner nuclear layer Present Regionally restricted 10C Expression is in some but not all cells located at the edge of the inner nuclear layer.
TS28: photoreceptor layer Absent 10C
TS28: photoreceptor layer outer segment Absent 10C
TS28: pigmented retinal epithelium Absent 10C
TS28: retina inner plexiform layer Absent 10C
TS28: retina outer plexiform layer Absent 10C

Specimen 10D: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: retina Absent 10D

Specimen not shown WT: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer II Strong
TS28: cortical layer III Strong
TS28: cortical layer V Strong
TS28: cortical layer VI Strong
TS28: cerebellum Purkinje cell layer Purkinje cell Present Expression is in the soma and dendritic trees of .Purkinje cells.
TS28: cerebellum granule cell layer cerebellar Golgi cell Present Single cells
TS28: cortical layer IV Absent

Specimen not shown KO: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: cerebellum Absent
TS28: cerebral cortex Absent
TS28: hippocampus Absent

Specimen not shown KO optic nerve: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: optic nerve Absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory