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Gene Expression Data
Assay Details
Assay
Reference: J:269548 Ramirez DM, et al., Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J Comp Neurol. 2008 Apr 10;507(5):1676-93
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7388174
Gene symbol: Cyp46a1
Gene name: cytochrome P450, family 46, subfamily a, polypeptide 1
Antibody: 1A7
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 7A: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: hippocampus CA1 pyramidal neuron Strong Regionally restricted 7A Expression is in the cell bodies and dendrites of pyramidal neurons.

Specimen 7B: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: hippocampus Absent 7B

Specimen 7C: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: dentate gyrus hilus interneuron Strong 7C
TS28: dentate gyrus granule cell layer Present 7C

Specimen 7D: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: hippocampus Absent 7D

Specimen 7E: postnatal month 14 (more )
Structure Cell Type Level Pattern Image Note
TS28: hippocampus CA1 pyramidal neuron Present Regionally restricted 7E Expression is in the cell bodies and dendrites of pyramidal neurons.

Specimen 7F: postnatal month 14; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Cell Type Level Pattern Image Note
TS28: hippocampus stratum radiatum interneuron Present Regionally restricted 7F

Specimen 8A: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Strong 8A Expression is in Purkinje cells and their associated dendritic trees.
TS28: cerebellum granule cell layer interneuron Strong Regionally restricted 8A
TS28: cerebellum granule cell layer cerebellar Golgi cell Strong Single cells 8A
TS28: cerebellum Trace Diffuse 8A Expression is in the neuropil.

Specimen 8B: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: cerebellum Absent 8B

Specimen 8C: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Strong 8C Expression is in Purkinje cells and their associated dendritic trees.
TS28: cerebellum granule cell layer interneuron Strong Regionally restricted 8C
TS28: cerebellum granule cell layer cerebellar Golgi cell Strong Single cells 8C
TS28: cerebellum Trace Diffuse 8C Expression is in the neuropil.

Specimen 8D: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: cerebellum Absent 8D

Specimen 9A: postnatal month 3 (more )
Structure Level Pattern Image Note
TS28: cortical layer II Present 9A Expression is in the somata of cortical neurons.
TS28: cortical layer III Present 9A Expression is in the somata of cortical neurons.
TS28: cortical layer V Present 9A Expression is in the somata of cortical neurons.
TS28: cortical layer VI Present 9A Expression is in the somata of cortical neurons.
TS28: neocortex layer Present Diffuse 9A Expression was diffuse in the neuropil in all layers of the cortex.
TS28: cortical layer I Absent 9A
TS28: cortical layer IV Absent 9A

Specimen 9B: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Absent 9B

Specimen 10A: postnatal month 3 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Strong 10A
TS28: retina inner nuclear layer Present Regionally restricted 10A Expression is in some but not all cells located at the edge of the inner nuclear layer.
TS28: pigmented retinal epithelium Present 10A
TS28: photoreceptor layer Absent 10A
TS28: photoreceptor layer outer segment Absent 10A
TS28: retina inner plexiform layer Absent 10A
TS28: retina outer plexiform layer Absent 10A

Specimen 10B: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: retina Absent 10B

Specimen not shown: postnatal month 3; Cyp46a1tm1Rus/Cyp46a1tm1Rus (more )
Structure Level Pattern Image Note
TS28: optic nerve Absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory