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Gene Expression Data
Assay Details
Assay
Reference: J:311142 Sun H, et al., Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing. Front Cell Dev Biol. 2021;9:690955
Assay type: RNA in situ
MGI Accession ID: MGI:7384743
Gene symbol: Adgra3
Gene name: adhesion G protein-coupled receptor A3
Probe: Mm-Adgra3 (827281)
Probe preparation: Antisense RNA
Results
Specimen 4B: postnatal day 0 (more )
Note: Double labeled: red - Adgra3; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlear inner hair cell Strong 4B
TS27: organ of Corti cochlear outer hair cell Strong 4B
TS27: spiral limbus interdental cell of cochlea Strong 4B
TS27: vestibular membrane Strong 4B Reissner's membrane.
TS27: stria vascularis Strong 4B
TS27: modiolus spiral ganglion neuron Strong 4B
TS27: cochlear duct border cell of cochlea Strong Regionally restricted 4B Tympanic border cells.
TS27: cochlear duct epithelium Claudius cell Strong Regionally restricted 4B Expressed in lesser epithelial ridge.
Specimen 4C: postnatal day 0; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Adgra3; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Claudius cell Present Regionally restricted 4C Only remained expression in lesser epithelial ridge and the lateral wall. Expression was low or undetectable in most regions.
Specimen 4D/D'D": postnatal day 0 (more )
Note: Double labeled: red - Adgra3; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium Claudius cell Strong Regionally restricted 4D" , 4D , 4D' Expressed in the lateral cochlear wall and the lesser epithelial ridge.
TS27: external spiral sulcus Strong 4D" , 4D , 4D'
TS27: greater epithelial ridge Present 4D" , 4D' , 4D At lower levels.
TS27: organ of Corti Present 4D" , 4D' , 4D At lower levels.
TS27: spiral limbus Present 4D" , 4D' , 4D At lower levels.
TS27: vestibular membrane Present 4D" , 4D' , 4D At lower levels.
TS27: cochlear duct border cell of cochlea Present Regionally restricted 4D" , 4D' , 4D At lower levels.
Specimen 4E/E'/E": postnatal day 0; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Adgra3; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct Claudius cell Present Regionally restricted 4E" , 4E' , 4E Markedly lower expression in lesser epithelial ridge and the lateral wall. Expression was low or undetectable in most regions.
TS27: stria vascularis Present 4E" , 4E' , 4E Markedly lower expression compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory