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Gene Expression Data
Assay Details
Assay
Reference: J:322165 Cunningham JG, et al., Early construction of the thalamocortical axon pathway requires c-Jun N-terminal kinase signaling within the ventral forebrain. Dev Dyn. 2022 Mar;251(3):459-480
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7382856
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: Anti-Tyrosine Hydroxylase (TYH)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 9B: embryonic day 13.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS21: forebrain Present 9B Positive nigrostriatal axons crossed the diencephalon-telencephalon boundary and enter the telencephalon.
TS21: diencephalon Present 9B
TS21: telencephalon Present 9B
Specimen 9C: embryonic day 13.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS21: forebrain Present 9C Positive nigrostriatal axons crossed the diencephalon-telencephalon boundary and enter the telencephalon.
TS21: diencephalon Present 9C
TS21: telencephalon Present 9C
Specimen 9E: embryonic day 13.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS21: diencephalon Present 9E
TS21: telencephalon Absent 9E Axons failed to reach the telencephalon.
Specimen 9F: embryonic day 13.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS21: diencephalon Present 9F Positive nigrostriatal axons were misrouted.
TS21: telencephalon Absent 9F Axons fail to reach the telencephalon.
Specimen 9G: embryonic day 15.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS23: corpus striatum Present 9G
Specimen 9H: embryonic day 15.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS23: corpus striatum Present 9H
Specimen 9I: embryonic day 15.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS23: corpus striatum Present 9I
Specimen 9J: embryonic day 15.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS23: corpus striatum Absent 9J
Specimen 9K: embryonic day 15.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS23: corpus striatum Absent 9K
TS23: diencephalon Present Regionally restricted 9K Positive axons misprojected ventrally.
Specimen 9L: embryonic day 15.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Th; red - Ntng1 (assay MGI:7382847).
Structure Level Pattern Image Note
TS23: corpus striatum Absent 9L
TS23: diencephalon Present Regionally restricted 9L Positive axons misprojected ventrally, and had formed a similar "U-shaped" bundle.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory