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Gene Expression Data
Assay Details
Assay
Reference: J:322165 Cunningham JG, et al., Early construction of the thalamocortical axon pathway requires c-Jun N-terminal kinase signaling within the ventral forebrain. Dev Dyn. 2022 Mar;251(3):459-480
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7382855
Gene symbol: Ppp1r1b
Gene name: protein phosphatase 1, regulatory inhibitor subunit 1B
Antibody: anti-DARPP32 (382 002)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8A: embryonic day 17.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Ppp1r1b; red - Th (assay MGI:7382854).
Structure Level Pattern Image Note
TS25: forebrain Present Regionally restricted 8A Positive striatonigral axons projected across the diencephalon-telencephalon boundary.
TS25: cerebral cortex Present 8A
TS25: diencephalon Present 8A
TS25: telencephalon Present 8A
TS25: midbrain Present Regionally restricted 8A Positive axons reached the substantia nigra.
Specimen 8B: embryonic day 17.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Ppp1r1b; red - Th (assay MGI:7382854).
Structure Level Pattern Image Note
TS25: cerebral cortex Present 8B
TS25: telencephalon Present 8B Postive axons failed to cross the diencephalon-telencephalon boundary.
TS25: corpus striatum Present 8B Positive fibers coalesced and became entangled.
TS25: diencephalon Absent 8B
Specimen 8C: embryonic day 17.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Structure Level Pattern Image Note
TS25: corpus striatum Present 8C
Specimen 8D: embryonic day 17.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Structure Level Pattern Image Note
TS25: diencephalon Present 8D Positive axons projected across the diencephalon-telencephalon boundary.
TS25: telencephalon Present 8D Positive axons projected across the diencephalon-telencephalon boundary.
Specimen 8E: embryonic day 17.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Structure Level Pattern Image Note
TS25: diencephalon Present 8E
Specimen 8F: embryonic day 17.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: corpus striatum Present 8F Positive axons were misrouted in the striatum. Positive fibers coalesced and became entangled.
Specimen 8G: embryonic day 17.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: telencephalon Present Regionally restricted 8G Postive axons failed to cross the diencephalon-telencephalon boundary.
TS25: diencephalon Absent 8G
Specimen 8H: embryonic day 17.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: diencephalon Absent 8H
Specimen 8I: postnatal day 0; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: green - Ppp1r1b; red - Th (assay MGI:7382854).
Structure Level Pattern Image Note
TS27: hypothalamus Present 8I Postive axons and Th+ axons traveled adjacently.
Specimen 8J: postnatal day 0; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: green - Ppp1r1b; red - Th (assay MGI:7382854).
Structure Level Pattern Image Note
TS27: hypothalamus Absent 8J Positive axons were missing.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory