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Gene Expression Data
Assay Details
Assay
Reference: J:322165 Cunningham JG, et al., Early construction of the thalamocortical axon pathway requires c-Jun N-terminal kinase signaling within the ventral forebrain. Dev Dyn. 2022 Mar;251(3):459-480
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7382854
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: Anti-Tyrosine Hydroxylase (TYH)
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen 8A: embryonic day 17.5; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: red - Th; green - Ppp1r1b (assay MGI:7382855).
Structure Level Pattern Image Note
TS25: forebrain Present Regionally restricted 8A Positive nigrostriatal axons projected across the diencephalon-telencephalon boundary.
TS25: diencephalon Present 8A
TS25: telencephalon Present 8A
TS25: midbrain Present Regionally restricted 8A Positive nigral axons projected from the substantia nigra to join the median forebrain bundle.
TS25: corpus striatum Present Diffuse 8A
Specimen 8B: embryonic day 17.5; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: red - Th; green - Ppp1r1b (assay MGI:7382855).
Structure Level Pattern Image Note
TS25: midbrain Present Regionally restricted 8B Expressed in the substantia nigra.
TS25: hypothalamus Present 8B Positive axons misprojected into the hypothalamus.
Specimen 8I: postnatal day 0; Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Double labeled: red - Th; green - Ppp1r1b (assay MGI:7382855).
Structure Level Pattern Image Note
TS27: hypothalamus Present Regionally restricted 8I Postive axons and Ppp1r1b+ axons traveled adjacently.
Specimen 8J: postnatal day 0; Mapk10tm1Flv/Mapk10tm1Flv, Mapk8tm1Rjd/Mapk8tm1Rjd, Mapk9tm1Flv/Mapk9tm1Flv, Tg(mI56i-cre,EGFP)1Kc/0 (more )
Note: Conditional mutant. Double labeled: red - Th; green - Ppp1r1b (assay MGI:7382855).
Structure Level Pattern Image Note
TS27: hypothalamus Present Regionally restricted 8J Positive axons misrouted ventrally, mainly in a "U-shaped" bundle.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory