Tg(Prnp-CHCHD10*S59L)U1Dkan
Transgene Detail
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| Symbol: |
Tg(Prnp-CHCHD10*S59L)U1Dkan |
| Name: |
transgene insertion U1, David Kang |
| MGI ID: |
MGI:7380626 |
| Synonyms: |
CHCHD10-S59L |
| Transgene: |
Tg(Prnp-CHCHD10*S59L)U1Dkan Location: unknown Genetic Position: ChrUN, Syntenic
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| Alliance: |
Tg(Prnp-CHCHD10*S59L)U1Dkan page
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| Transgene Type: |
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Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prnp-CHCHD10*S59L)U1Dkan expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CHCHD10 (400916) |
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contains S59L mutation |
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Mutation details: The transgenic construct contains a FLAG-tagged CHCHD10 S59L mutant cDNA cloned into the expression vector MoPrP.Xho, which contains the mouse genomic prion promoter (Prnp) sequence.
(J:306293)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:306293 Liu T, et al., CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia. FASEB J. 2020 Jun;34(6):8493-8509 |
| All: |
3 reference(s) |
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Analysis Tools
