Tg(Nppa*-lacZ)r-0.25Vmc
Transgene Detail
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| Symbol: |
Tg(Nppa*-lacZ)r-0.25Vmc |
| Name: |
transgene insertion r-0.25, Vincent M Christoffels |
| MGI ID: |
MGI:7380394 |
| Synonyms: |
0.25rNppacTnILacZ, ANF-cTnI-lacZ |
| Transgene: |
Tg(Nppa*-lacZ)r-0.25Vmc Location: unknown
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| Alliance: |
Tg(Nppa*-lacZ)r-0.25Vmc page
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: The 638/-138 bp rat Nppa regulatory region sequence, containing silencer and enhancer sequences, is placed upstream of the 230/+126 bp Tnni3 promoter sequence (and the chimeric silencer-promoter is flanked by chicken beta-globin locus insulator sequence), followed by a beta-globin/IgG chimeric intron, nls sequence, the lacZ beta-galactosidase gene and bovine GH poly(A) signal sequence. The Nppa regulatory sequence drives expression in the embryonic atrial and ventricular chamber myocardium but represses expression in the atrioventricular canal.
(J:76656)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:76656 Habets PE, et al., Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 2002 May 15;16(10):1234-46 |
| All: |
2 reference(s) |
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Analysis Tools
