Tenm2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:116586 Li H, et al., Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci. 2006 Oct;33(2):136-49
Assay type:	RNA in situ
MGI Accession ID:	MGI:7367171
Gene symbol:	Tenm2
Gene name:	teneurin transmembrane protein 2

Probe:	Odz2 cDNA1
Probe preparation:	Antisense labelled with S35 RNA

Results

Specimen 5B: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: cortical plate	Present	Graded	5B	Expression is in a rostral low to caudal high gradient.
TS23: corpus striatum	Present		5B
TS23: hippocampus	Present		5B
TS23: main olfactory bulb	Present		5B
TS23: thalamus	Present		5B

Specimen 5F: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Present	Graded	5F	Expression is differentiating cells in a rostral low to caudal high gradient.
TS26: insular cortex	Present		5F
TS26: neocortex region	Present	Regionally restricted	5F	Expression is in the orbital area.

Specimen 6B: postnatal day 2 (more

)

Structure	Level	Pattern	Image	Note
TS27: cortical layer V	Strong	Graded	6B	Expression is rostral low and caudal high.
TS27: hippocampus CA1	Strong		6B
TS27: visual cortex	Strong	Regionally restricted	6B	Expression is in layer V.
TS27: corpus striatum	Present		6B
TS27: insular cortex	Present		6B
TS27: thalamus	Present		6B
TS27: neocortex region	Present	Regionally restricted	6B	Expression is in the orbital area.
TS27: cortical layer I	Present	Graded	6B	Expression is rostral low and caudal high.
TS27: cortical layer II	Present	Graded	6B	Expression is rostral low and caudal high.
TS27: cortical layer III	Present	Graded	6B	Expression is rostral low and caudal high.
TS27: cortical layer IV	Present	Graded	6B	Expression is rostral low and caudal high.
TS27: cortical layer VI	Present	Graded	6B	Expression is rostral low and caudal high.
TS27: dentate gyrus	Weak		6B
TS27: hippocampus CA3	Weak		6B

Specimen 7B: postnatal day 7 (more

)

Structure	Level	Pattern	Image	Note
TS28: cortical layer V	Strong	Graded	7B	Expression is rostral low and caudal high.
TS28: cortical layer I	Present	Graded	7B	Expression is rostral low and caudal high.
TS28: cortical layer II	Present	Graded	7B	Expression is rostral low and caudal high.
TS28: cortical layer III	Present	Graded	7B	Expression is rostral low and caudal high.
TS28: cortical layer IV	Present	Graded	7B	Expression is rostral low and caudal high.
TS28: cortical layer VI	Present	Graded	7B	Expression is rostral low and caudal high.
TS28: hippocampus	Present	Uniform	7B

Specimen 8B: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex	Present	Graded	8B	Expression is in a high dorsal/medial to low ventral/lateral gradient.
TS23: dorsal thalamus	Present	Regionally restricted	8B	Expression is in in the posterior complex and centrolateral nucleus and is absent in the ventroposterior nucleus.
TS23: dorsal lateral geniculate nucleus	Present		8B
TS23: geniculate thalamic group	Present	Regionally restricted	8B	Expression is in the ventral subdivision of medial geniculate nucleus.
TS23: thalamus	Present		8B	Including the ventral thalamus.

Specimen 8F: postnatal day 2 (more

)

Structure	Level	Pattern	Image	Note
TS27: cerebral cortex	Present	Graded	8F	Expression is in in a high medial and low lateral gradient.
TS27: dorsal lateral geniculate nucleus	Strong		8F
TS27: hippocampus CA1	Strong		8F
TS27: lateral posterior thalamic nucleus	Strong		8F
TS27: visual cortex	Strong		8F
TS27: central lateral thalamic nucleus	Present		8F
TS27: posterior thalamic group	Present		8F
TS27: hypothalamus	Present	Regionally restricted	8F
TS27: dentate gyrus	Weak		8F
TS27: hippocampus CA3	Weak		8F

Specimen 9B: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: neocortex	Present	Graded	9B	Expression is graded from rostral low to caudal high.

Specimen 9B': embryonic day 15.5; Emx2^tm1Pgr/Emx2^tm1Pgr (more

)

Structure	Level	Pattern	Image	Note
TS23: neocortex	Weak	Graded	9B'	In this mutant expression is graded from rostral low to caudal high, but the expression areas have shrunk/shifted towards the posterior part.

Specimen 10C: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Present	Graded	10C	Expression is in a rostral low to caudal high gradient.

Specimen 10C': embryonic day 18.5; Emx2^tm1Pgr/Emx2^tm1Pgr (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Weak	Regionally restricted	10C'	In this mutant the expressing region has also shifted to the caudal pole compared to wild-type.

Specimen 10D: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Present	Graded	10D	Expression is in a rostral low to caudal high gradient.

Specimen 10D': embryonic day 18.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Strong		10D'	In this mutant the expressing region has extended to the most anterior areas compared to wild-type.

Specimen not shown: embryonic day 10.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS17: forebrain	Weak

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