Tcf4 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:116586 Li H, et al., Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci. 2006 Oct;33(2):136-49
Assay type:	RNA in situ
MGI Accession ID:	MGI:7367163
Gene symbol:	Tcf4
Gene name:	transcription factor 4

Probe:	ME2 cDNA
Probe preparation:	Antisense labelled with S35 RNA

Results

Specimen 3B: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex subventricular zone	Strong	Graded	3B	Expression is in a rostral low to caudal high gradient.
TS23: hippocampus	Strong		3B
TS23: cerebral cortex ventricular layer	Present	Graded	3B	Expression is in a rostral low to caudal high gradient.

Specimen 3B': embryonic day 15.5; Emx2^tm1Pgr/Emx2^tm1Pgr (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex subventricular zone	Present	Graded	3B'	In this mutant the expression area was reduced and had shifted towards the caudal pole of cortex.
TS23: cerebral cortex ventricular layer	Weak	Graded	3B'	In this mutant the expression area was reduced and had shifted towards the caudal pole of cortex.

Specimen 4A: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex subventricular zone	Strong	Graded	4A	Expression is in a high rostral to low caudal gradient.
TS26: cerebral cortex ventricular zone	Strong	Graded	4A	Expression is in a high rostral to low caudal gradient.
TS26: cortical plate	Strong	Graded	4A	Expression is in a high rostral to low caudal gradient.
TS26: cortical subplate	Strong	Graded	4A	Expression is in a high rostral to low caudal gradient.
TS26: hippocampus	Strong		4A

Specimen 4A': embryonic day 18.5; Emx2^tm1Pgr/Emx2^tm1Pgr (more

)

Structure	Level	Pattern	Image	Note
TS26: parietal cortex	Strong	Regionally restricted	4A'	Expression is in the medial somatosensory area that declines caudally.
TS26: neocortex	Present	Graded	4A'	Expression is reduced in more anterior parts of neocortex resulting in a reversal of the gradient seen in wild type.

Specimen 4B: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex subventricular zone	Strong	Graded	4B	Expression is in a high rostral to low caudal gradient.
TS26: cerebral cortex ventricular zone	Strong	Graded	4B	Expression is in a high rostral to low caudal gradient.
TS26: cortical plate	Strong	Graded	4B	Expression is in a high rostral to low caudal gradient.
TS26: cortical subplate	Strong	Graded	4B	Expression is in a high rostral to low caudal gradient.
TS26: hippocampus	Strong		4B

Specimen 4B': embryonic day 18.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Strong	Graded	4B'	Expression in this mutant is stronger in intermediate parts of the cortex and lower at the most anterior margin.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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