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Gene Expression Data
Assay Details
Assay
Reference: J:280029 Mizutani Y, et al., Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis. Cancer Res. 2019 Oct 15;79(20):5367-5381
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7345574
Gene symbol: Islr
Gene name: immunoglobulin superfamily containing leucine-rich repeat
Reporter: ZsGreen
Direct Detection
Results
Specimen 1C - bone marrow: postnatal day 56; Islrtm1.1(HBEGF,cre)Mat/Islr+ (more )
Structure Cell Type Level Pattern Image Note
TS28: bone marrow mesenchymal stem cell of the bone marrow Present Single cells 1C top Expressing cells localized adjacent to the trabecular bones and sinusoids and the parenchyma of the bone marrow.
Specimen 1C - pancreas: postnatal day 56; Islrtm1.1(HBEGF,cre)Mat/Islr+ (more )
Note: Double labeled: green - Islr reporter; red - Des (assay MGI:7345894).
Structure Cell Type Level Pattern Image Note
TS28: pancreas pancreatic stellate cell Present Single cells 1C bottom Coexpressed with desmin.
Specimen S2C - bone marrow: postnatal day 56; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Islrtm1.1(HBEGF,cre)Mat/Islr+ (more )
Note: Conditional mutant. Triple labeled: green - Islr; white - Runx2 (assay MGI:7345946); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS28: bone marrow Present Single cells S2C top left
TS28: bone marrow osteoblast Absent S2C top left
Specimen S2C - growth plate: postnatal day 56; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Islrtm1.1(HBEGF,cre)Mat/Islr+ (more )
Note: Conditional mutant. Triple labeled: green - Islr; white - Sox9 (assay MGI:7345947); red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS28: long bone epiphyseal plate Present Single cells S2C top right
TS28: long bone epiphyseal plate chondroblast Absent S2C top right
Specimen S2C -pancreas: postnatal day 56; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Islrtm1.1(HBEGF,cre)Mat/Islr+ (more )
Note: Conditional mutant. Triple labeled: green - Islr; white - Acta2 (assay MGI:7345948); red - Cre reporter.
Structure Level Pattern Image Note
TS28: pancreas Present Single cells S2C bottom right
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory