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Gene Expression Data
Assay Details
Assay
Reference: J:182446 Kon N, et al., Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem. 2012 Feb 10;287(7):5102-11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7343923
Gene symbol: Gcg
Gene name: glucagon
Antibody: anti-glucagon
Results
Specimen 3Aiii: postnatal month 1; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present 3Aiii
Specimen 3Avi: postnatal month 1; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present 3Avi Similar as in the control.
Specimen 4Biv: postnatal month 1; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 4Biv Expressed in the periphery of the islet.
Specimen 4Bv: postnatal month 6; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 4Bv Expressed in the periphery of the islet.
Specimen 4Bvi: postnatal month 9; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 4Bvi Expressed in the periphery of the islet.
Specimen 4Bx: postnatal month 1; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 4Bx Expressed in the periphery of the islet, similar as in the control.
Specimen 4Bxi: postnatal month 6; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present 4Bxi The morphology of islets became increasingly irregular with frequent infiltration of alpha-cells in the middle of the islets.
Specimen 4Bxii: postnatal month 9; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Widespread 4Bxii Disruption of the islet structure was worsened. The remaining cells in the islets were positive alpha-cells.
Specimen 6C: postnatal month 9; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 6C Expressed in the periphery of the islet.
Specimen 6E: postnatal month 9; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Widespread 6E Disruption of the islet structure was worsened. The remaining cells in the islets were positive alpha-cells.
Specimen 6G: postnatal month 9; Huwe1tm1Wgu/Y, Trp53tm1Thl/Trp53tm1Thl (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 6G Expressed in the periphery of the islet, similar as in the control.
Specimen 6I: postnatal month 9; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0, Trp53tm1Thl/Trp53tm1Thl (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Regionally restricted 6I Expressed in the periphery of the islet, similar as in the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory