Tg(Rr279*-EGFP)nPE1coreMrub
Transgene Detail
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| Symbol: |
Tg(Rr279*-EGFP)nPE1coreMrub |
| Name: |
transgene insertion nPE1core, Marcelo Rubinstein |
| MGI ID: |
MGI:7343823 |
| Synonyms: |
nPE1core, nPE1-corePomc-EGFP |
| Transgene: |
Tg(Rr279*-EGFP)nPE1coreMrub Location: unknown
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| Alliance: |
Tg(Rr279*-EGFP)nPE1coreMrub page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing region 6.5-13 kb upstream of the Pomc gene transcription start site with enhancer Rr280 deleted but a modified Rr279 (where the sequence flanking the 144 bp core was deleted from the 630 bp region) still present, and the Pomc gene, including 0.8 kb of upstream and 8 kb of downstream sequence, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The transgene is expressed in hypothalamic arcuate neurons and in the pitutiary gland during embryonic development.
(J:176451)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:176451 Franchini LF, et al., Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15270-5 |
| All: |
1 reference(s) |
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Analysis Tools
