Tg(Rr280-EGFP)nPE2Mrub
Transgene Detail
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| Symbol: |
Tg(Rr280-EGFP)nPE2Mrub |
| Name: |
transgene insertion nPE2, Marcelo Rubinstein |
| MGI ID: |
MGI:7343821 |
| Synonyms: |
nPE2-EGFP |
| Transgene: |
Tg(Rr280-EGFP)nPE2Mrub Location: unknown
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| Alliance: |
Tg(Rr280-EGFP)nPE2Mrub page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing region 9-13 kb upstream of the Pomc gene transcription start site with enhancer Rr279 deleted but Rr280 still present, and the Pomc gene, including 0.8 kb of upstream and 8 kb of downstream sequence, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The deleted region 0.8-9 kb upstream of Pomc contains pituitary enhancer Rr181. The transgene is expressed in hypothalamic arcuate neurons during embryonic development.
(J:176451)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:176451 Franchini LF, et al., Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15270-5 |
| All: |
2 reference(s) |
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Analysis Tools
