Tg(Rr280-GH1)10Mrub
Transgene Detail
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| Symbol: |
Tg(Rr280-GH1)10Mrub |
| Name: |
transgene insertion 10, Marcelo Rubinstein |
| MGI ID: |
MGI:7341858 |
| Transgene: |
Tg(Rr280-GH1)10Mrub Location: unknown
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| Alliance: |
Tg(Rr280-GH1)10Mrub page
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| Strain of Origin: |
either: (C57BL/6 x CBA)F2 or (C57BL/6 x DBA/2)F2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Rr280-GH1)10Mrub expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CSH1 (1442) |
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Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing region 9-13 kb upstream of the Pomc gene transcription start site with enhancer Rr279 (nPE1) deleted (585 bp) but Rr280 (nPE2) still present, the Herpes simplex virus TK gene minimal promoter and the human growth hormone gene. The transgene is expressed in hypothalamic arcuate neurons but not in pituitary melanotrophs and corticotrophs during embryonic development.
(J:97636)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:97636 de Souza FS, et al., Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. Mol Cell Biol. 2005 Apr;25(8):3076-86 |
| All: |
1 reference(s) |
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Analysis Tools
