Tg(Rr596*-GH1)12Mrub
Transgene Detail
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| Symbol: |
Tg(Rr596*-GH1)12Mrub |
| Name: |
transgene insertion 12, Marcelo Rubinstein |
| MGI ID: |
MGI:7341863 |
| Synonyms: |
Tg(GH1)12Mrub |
| Transgene: |
Tg(Rr596*-GH1)12Mrub Location: unknown
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| Alliance: |
Tg(Rr596*-GH1)12Mrub page
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| Strain of Origin: |
either: (C57BL/6 x CBA)F2 or (C57BL/6 x DBA/2)F2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Rr596*-GH1)12Mrub expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CSH1 (1442) |
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Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing sequence 9-13 kb upstream of the Pomc gene transcription start site (with the two enhancers Rr279 (nPE1) and Rr280 (nPE2) deleted (585 bp, 172 bp)), the Herpes simplex virus TK gene minimal promoter and the human growth hormone gene gene. The transgene is expressed in neither hypothalamic arcuate neurons nor in pituitary melanotrophs and corticotrophs during embryonic development.
(J:97636)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:97636 de Souza FS, et al., Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. Mol Cell Biol. 2005 Apr;25(8):3076-86 |
| All: |
1 reference(s) |
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Analysis Tools
