Axin2 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:205338 Kuss P, et al., Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014 Jan 1;385(1):83-93
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:7336214
Gene symbol:	Axin2
Gene name:	axin 2

Reporter:	lacZ
	Direct Detection

Results

8A WT ©

Specimen 8A WT: embryonic day 14.5; Axin2^tm1Wbm/Axin2⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS22: metacarpus cartilage condensation	osteoblast	Strong	Regionally restricted	8A WT	Strong signal in lateral hypertrophic regions and cortical osteoblasts.
TS22: perichondrium		Present	Regionally restricted	8A WT	Only expressed in joint areas.

8A Spdh ©

Specimen 8A Spdh: embryonic day 14.5; Axin2^tm1Wbm/Axin2⁺, Hoxd13^spdh/Hoxd13^spdh (more

)

Structure	Level	Pattern	Image	Note
TS22: metacarpus cartilage condensation	Absent		8A Spdh
TS22: perichondrium	Present		8A Spdh	Intensified staining in cells adjacent to the cartilage surrounding the complete anlage was seen in a fashion resembling wild-type carpals.

8A right ©

Specimen 8A WT carpals: embryonic day 14.5; Axin2^tm1Wbm/Axin2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS22: perichondrium	Present		8A right	Expressed in cells adjacent to the cartilage surrounding the complete carpals.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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