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Gene Expression Data
Assay Details
Assay
Reference: J:297683 Fernandez-Guerrero M, et al., Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30509-30519
Assay type: RNA in situ
MGI Accession ID: MGI:7335077
Gene symbol: Hoxc13
Gene name: homeobox C13
Probe: Hoxc13 probe3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: limb Present Regionally restricted 1C Hoxc13 Expression was detected in late E12.5 limb bud ectoderm and appeared more restricted to the tip.

Specimen 1D whole mount: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 1D Hoxc13 Expression was detected in the forelimb digit tips at E14.5.

Specimen 1E E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 1E Hoxc13 E14.5 Expression was detected in the forelimb digit tips.

Specimen 1E E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: forelimb phalanx Present Regionally restricted 1E Hoxc13 E16.5 Expression became progressively confined to the dorsal ectoderm over the last phalanx.

Specimen 1E Newborn: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: nail matrix Present 1E Hoxc13 Newborn

Specimen 4D Newborn: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: nail matrix Present 4D Newborn Hoxc13

Specimen 4D P14: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: nail matrix Present 4D P14 Hoxc13

Specimen 4E Newborn: postnatal newborn; Hoxcem3Ddu/Hoxcem3Ddu (more )
Structure Level Pattern Image Note
TS27: nail matrix Weak 4E Newborn Hoxc13

Specimen 4E P14: postnatal day 14; Hoxcem3Ddu/Hoxcem3Ddu (more )
Structure Level Pattern Image Note
TS28: nail matrix Weak 4E P14 Hoxc13

Specimen 5B CTRL: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: nail matrix Present 5B P7 CTRL Hoxc13

Specimen 5B HoxCdel(EC1-EC2)/-: postnatal day 7; Hoxcem3Ddu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS28: nail matrix Weak 5B P7 HoxCdel(EC1-EC2)/- Hoxc13

Specimen 5C CTRL: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: hair follicle Present 5C CTRL Hoxc13

Specimen 5C HoxCdel(EC1-EC2)/-: postnatal day 7; Hoxcem3Ddu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS28: hair follicle Present 5C HoxCdel(EC1-EC2)/- Hoxc13 A lower level of Hoxc13 expression was noted in the mutant compared to control.

Specimen 5D CTRL Forelimb: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 5D Forelimb CTRL Expression was detected in the ectoderm of the digit tips.

Specimen 5D HoxCdel(EC1-EC2)/- Forelimb: embryonic day 14.5; Hoxcem3Ddu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS22: forelimb digit Absent 5D Forelimb HoxCdel(EC1-EC2)/- Hoxc13 expression was below detection level in the ectoderm of the digit tips of the mutant.

Specimen 5D CTRL Tail: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: tail mesenchyme Present 5D Tail CTRL

Specimen 5D HoxCdel(EC1-EC2)/- Tail: embryonic day 14.5; Hoxcem3Ddu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS22: tail mesenchyme Present 5D Tail HoxCdel(EC1-EC2)/- Expression persisted at a normal level in the tail mesenchyme of the mutant.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory