Gene Expression Data
Assay Details
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Assay
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Reference:
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J:161878
Hudon V, et al., Renal tumour suppressor function of the Birt-Hogg-Dube syndrome gene product folliculin. J Med Genet. 2010 Mar;47(3):182-9
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7334888
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Gene symbol:
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Mapk1
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Gene name:
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mitogen-activated protein kinase 1
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Antibody:
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anti-p-ERK1/2
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Assay notes:
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The antibody used recognizes the phosphorylated form of the protein. The specificity of the antibody used was not detailed; both family members have been annotated.
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Results
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Specimen
5G:
postnatal adult; FlcnGt(RRX115)Byg/Flcn +
(more  )
Note: multilocular and large cyst area
Specimen
5G:
(close  )
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Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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FlcnGt(RRX115)Byg/Flcn+
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Note:
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multilocular and large cyst area
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS28: metanephros |
epithelial cell |
Strong |
Regionally restricted |
5G
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Expressed in the epithelial cells lining large cysts from mutant polycystic kidneys.
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Specimen
5H:
postnatal adult; FlcnGt(RRX115)Byg/Flcn +
(more )
Note: small single cyst area
Specimen
5H:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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FlcnGt(RRX115)Byg/Flcn+
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Note:
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small single cyst area
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS28: metanephros |
epithelial cell |
Present |
Regionally restricted |
5H
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Almost absent in epithelial cells lining the small cysts from monocystic kidneys. High expression in the epithelial cells lining large cysts from mutant polycystic kidneys.
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Specimen
5I:
postnatal adult; FlcnGt(RRX115)Byg/Flcn +
(more )
Note: small single cyst area
Specimen
5I:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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FlcnGt(RRX115)Byg/Flcn+
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Note:
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small single cyst area
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS28: metanephros |
epithelial cell |
Strong |
Regionally restricted |
5I
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Expressed in some pockets of cells lining several cysts, which were stained negative for p-S6.
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Specimen
S5B:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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FlcnGt(RRX115)Byg/Flcn+
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: renal tubule |
Present |
Spotted |
S5B
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Sporadic expression in normal kidney tubules.
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Analysis Tools
