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Gene Expression Data
Assay Details
Assay
Reference: J:326355 Bademci G, et al., Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204084119
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7329772
Gene symbol: Myo7a
Gene name: myosin VIIA
Antibody: anti-Myo7a (MYO7A 138-1)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6A: postnatal week 14 (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Present 6A
Specimen 6B: postnatal week 14 (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Present 6B
Specimen 6C: postnatal week 14 (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Present 6C
Specimen 6D: postnatal week 14 (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Present 6D
Specimen not shown: postnatal week 14; Minar2tm1b(KOMP)Wtsi/Minar2+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Present Similar appearance to that of wild type.
Specimen 6E: postnatal week 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Weak Patchy 6E Patches of hair cell loss at varying localtions along cochlear duct, interspersed with regions of scattered hair cells loss.
Specimen 6F: postnatal week 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Weak 6F Patches of hair cell loss at varying localtions along cochlear duct, interspersed with regions of scattered hair cells loss.
Specimen 6G: postnatal week 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Trace Scattered 6G Patches of hair cell loss at varying localtions along cochlear duct, interspersed with regions of scattered hair cells loss.
Specimen 6H: postnatal week 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - Myo7a; magenta - phalloidin
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti auditory hair cell Trace 6H Patches of hair cell loss at varying localtions along cochlear duct, interspersed with regions of scattered hair cells loss.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory