Tg(Col2a1-Runx2*)4Tok
Transgene Detail
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| Symbol: |
Tg(Col2a1-Runx2*)4Tok |
| Name: |
transgene insertion 4, Toshihisa Komori |
| MGI ID: |
MGI:2447360 |
| Synonyms: |
Col2a1-DN-Cbfa1, Tg(Col2a1-Runx2DN)4Tok |
| Transgene: |
Tg(Col2a1-Runx2*)4Tok Location: unknown
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| Alliance: |
Tg(Col2a1-Runx2*)4Tok page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Col2a1-Runx2*)4Tok expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Runx2 (MGI:99829) |
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Mutation details: A cDNA fragment encoding the runt domain and N-terminus of mouse Runx2 (beginning at exon 2) was cloned between the promoter and enhancer elements of Col2a1 to produce a dominant negative transgene. The Col2a1 promoter is active in chondrocytes. Transgene expression was confirmed by Northern blot analysis of RNA extracted from the head or trunk of day E12.5 transgenic embryos.
(J:68793)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:68793 Ueta C, et al., Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol. 2001 Apr 2;153(1):87-100 |
| All: |
1 reference(s) |
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Analysis Tools
