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Gene Expression Data
Assay Details
Assay
Reference: J:311932 White AK, et al., Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing. Development. 2021 Oct 15;148(20):dev199591
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7327186
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 4A E12.5 Control: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS20: pallium radial glial cell Present 4A E12.5 Control
Specimen 4A E12.5 Rnu11 cKO: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS20: pallium radial glial cell Present 4A E12.5 Rnu11 cKO There was a significant increase in the percentage of mitotic radial glial cells in prometaphase in this mutant compared with control.
Specimen 4A E12.5 dKO: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS20: pallium radial glial cell Present 4A E12.5 dKO There was a significant increase in the percentage of mitotic radial glial cells in prometaphase in this mutant compared with control.
Specimen 4A E13.5 Control: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS21: pallium radial glial cell Present 4A E13.5 Control
Specimen 4A E13.5 Rnu11 cKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS21: pallium radial glial cell Present 4A E13.5 Rnu11 cKO There was a significant increase in the percentage of mitotic radial glial cells in prometaphase in this mutant compared with control.
Specimen 4A E13.5 dKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS21: pallium radial glial cell Present 4A E13.5 dKO There was a significant increase in the percentage of mitotic radial glial cells in prometaphase in this mutant compared with control. There was a reduction in the percentage of radial glial cells in telophase.
Specimen 4A E14.5 Control: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS22: pallium radial glial cell Present 4A E14.5 Control
Specimen 4A E14.5 Rnu11 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS22: pallium radial glial cell Present 4A E14.5 Rnu11 cKO There was a significant increase in the percentage of mitotic radial glial cells in prometaphase in this mutant compared with control. There was a reduction in the percentage of radial glial cells in telophase.
Specimen 4A E14.5 dKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:7327176).
Structure Cell Type Level Pattern Image Note
TS22: pallium radial glial cell Present 4A E14.5 dKO There was a significant increase in the percentage of mitotic radial glial cells in prometaphase in this mutant compared with control. There was a reduction in the percentage of radial glial cells in telophase.
Specimen 5A E12.5 Control: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11+ (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS20: pallium radial glial cell Present 5A E12.5 Control
Specimen 5A E12.5 Rnu11 cKO: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS20: pallium radial glial cell Present 5A E12.5 Rnu11 cKO Expression is similar to controls.
Specimen 5A E12.5 dKO: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS20: pallium radial glial cell Present 5A E12.5 dKO Expression is similar to controls.
Specimen 5A E13.5 Control: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11+ (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS21: pallium radial glial cell Present 5A E13.5 Control
Specimen 5A E13.5 Rnu11 cKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS21: pallium radial glial cell Present 5A E13.5 Rnu11 cKO
Specimen 5A E13.5 dKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS21: pallium radial glial cell Present 5A E13.5 dKO In this mutant there was a significant decrease in the percentage of S-phase radial glial cells compared with control.
Specimen 5A E14.5 Control: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11+ (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS22: pallium radial glial cell Present 5A E14.5 Control
Specimen 5A E14.5 Rnu11 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS22: pallium radial glial cell Present 5A E14.5 Rnu11 cKO In this mutant there was a significant decrease in the percentage of S-phase radial glial cells compared with control.
Specimen 5A E14.5 dKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Rnu11tm1.1Rank/Rnu11tm1.1Rank, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled with BrdU (magenta) and EdU (blue).
Structure Cell Type Level Pattern Image Note
TS22: pallium radial glial cell Present 5A E14.5 dKO In this mutant there was a significant decrease in the percentage of S-phase radial glial cells compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory