Tg(Thy1-CAST)12Rnix
Transgene Detail
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| Symbol: |
Tg(Thy1-CAST)12Rnix |
| Name: |
transgene insertion 12, Ralph A Nixon |
| MGI ID: |
MGI:7311562 |
| Synonyms: |
hCAST Tg |
| Transgene: |
Tg(Thy1-CAST)12Rnix Location: unknown
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| Alliance: |
Tg(Thy1-CAST)12Rnix page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-CAST)12Rnix expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CAST (831) |
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Mutation details: The transgenic construct contains a mouse Thy1.1 (thymocyte differentiation antigen) promoter directing expression the human CAST (calpastatin) coding sequence. Founder line 12 expressed the highest amount of CAST protein (17 fold higher than controls).
(J:142368)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:142368 Rao MV, et al., Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci. 2008 Nov 19;28(47):12241-54 |
| All: |
1 reference(s) |
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Analysis Tools
