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Gene Expression Data
Assay Details
Assay
Reference: J:313926 Cichon MA, et al., Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and Lymphoid Organs. Front Cell Dev Biol. 2020;8:608876
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7294409
Gene symbol: Rtn1
Gene name: reticulon 1
Results
Specimen 1B mouse: postnatal adult (more )
Structure Level Pattern Image Note
TS28: epidermis Strong Regionally restricted 1B mouse Strong expression restricted to epidermal dendritically shaped cells.
TS28: dermis Absent 1B mouse
Specimen 1D skin section MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS28: epidermis Langerhans cell Present 1D skin section MHCII Expression in Langerhans cells in epidermis, co-expressed with MHCII.
TS28: dermis dendritic cell Absent 1D skin section MHCII No expression in MHCII+ dendritic cells in dermis.
Specimen 1D epidermal sheets MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1D epidermal sheets MHCII Co-expression with MHCII.
Specimen 1C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1D CD207 Co-expression with CD207.
Specimen 1C CD3: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd3g (assay MGI:7294412).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1D CD3 Expression not co-localized with CD3.
Specimen 2A E16.5: embryonic day 16.5 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS24: skin Present Single cells 2A E16.5 , 2A E16.5 inset Authors report co-expression with CD45 in a few round to polygonal cells
Specimen 2A E18.5: embryonic day 18.5 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS26: skin Present Regionally restricted 2A E18.5 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd1: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2A pd1 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd1 inset: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; blue - Cd3g (assay MGI:7294412).
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2A pd1 inset Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd3: postnatal day 3 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2A pd3 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd7: postnatal day 7 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 2A pd7 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2B pd1: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; red - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS27: epidermis Langerhans cell Weak 2B pd1 Continuum of low to high expression in Langerhans cells during postnatal period.
Specimen 2B pd3: postnatal day 3 (more )
Note: Double labeled: green - Rtn1; red - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS27: epidermis Langerhans cell Present 2B pd3 Continuum of low to high expression in Langerhans cells during postnatal period.
Specimen 2B pd7: postnatal day 7 (more )
Note: Double labeled: green - Rtn1; red - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS28: epidermis Langerhans cell Strong 2B pd7 Continuum of low to high expression in Langerhans cells during postnatal period.
Specimen 2D E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: skin Present Regionally restricted 2D E16.5 Expression reminiscent of nerve structures.
Specimen 2D E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: dermis Present Regionally restricted 2D dermal sheets E18.5 Expression reminiscent of nerve structures.
Specimen 2D pd1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: dermis Absent 2D dermal sheets pd1
Specimen 2E E16.5: embryonic day 16.5 (more )
Note: Double labeled: green - Rtn1; red - Nefm (assay MGI:7294414).
Structure Level Pattern Image Note
TS24: skin Present Regionally restricted 2E E16.5 Authors report co-localization with neurofilament expression.
Specimen 2E E18.5: embryonic day 18.5 (more )
Note: Double labeled: green - Rtn1; red - Nefm (assay MGI:7294414).
Structure Level Pattern Image Note
TS26: dermis Present Regionally restricted 2E E18.5 Authors report co-localization with neurofilament expression.
Specimen 2E pd1: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; red - Nefm (assay MGI:7294414).
Structure Level Pattern Image Note
TS27: dermis Absent 2E pd1
Specimen 3C MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C MHCII inset (lower) , 3C MHCII , 3C MHCII inset (upper) Expression co-localized with MHCII in some, but not all, cells.
Specimen 3C CD11c: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Itgax (assay MGI:7294415).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C CD11c inset (lower) , 3C CD11c inset (upper) , 3C CD11c Expression co-localized with CD11c in some, but not all, cells.
Specimen 3C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C CD207 , 3C CD207 inset (upper) , 3C CD207 inset (lower) There was no coexpression with CD207.
Specimen 3C F4/80: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Adgre1 (assay MGI:7294416).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C F4/80 inset (lower) , 3C F4/80 inset (upper) , 3C F4/80 Co-expression with F4/80 only in a few cells.
Specimen 4C MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C MHCII inset , 4C MHCII Expression co-localized with MHCII.
Specimen 4C CD11c: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Itgax (assay MGI:7294415).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C Cd11c , 4C Cd11c inset (lower) , 4C Cd11c inset (upper) Expression colocalized with CD11c.
Specimen 4C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C CD207 inset (upper) , 4C CD207 inset (lower) , 4C CD207 Expression colocalized with CD207.
Specimen 4C F4/80: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Adgre1 (assay MGI:7294416).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C F4/80 inset (lower) , 4C F4/80 , 4C F4/80 inset (upper) Expression in majority of F4/80+ cells.
Specimen 5C MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C MHCII , 5C MHCII inset (upper) , 5C MHCII inset (lower) Authors report co-expression with MHCII in a minute population of cells.
Specimen 5C CD11c: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Itgax (assay MGI:7294415).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C CD11c inset (lower) , 5C CD11c , 5C CD11c inset (upper) Authors report co-expression with CD11c in a minute population of cells.
Specimen 5C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C CD207 inset (lower) , 5C CD207 inset (upper) , 5C CD207 Co-expression with CD207 in several cells localized mainly in white pulp.
Specimen 5C F4//80: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Adgre1 (assay MGI:7294416).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C F4/80 inset (lower) , 5C F4/80 , 5C F4/80 inset (upper) RTN1A , 5C F4/80 inset (upper) , 5C F4/80 inset (upper) F4/80 Expression co-localized with F4/80 in some cells
Specimen S3A: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell Present S3A
Specimen S3C B220 thymus: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Ptprc (assay MGI:7294413).
Structure Cell Type Level Pattern Image Note
TS28: thymus B cell Absent S3C B220 thymus
Specimen S3C B220 lymph node: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Ptprc (assay MGI:7294413).
Structure Cell Type Level Pattern Image Note
TS28: lymph node B cell Absent S3C B220 lymph node
Specimen S3C B220 spleen: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Ptprc (assay MGI:7294413).
Structure Cell Type Level Pattern Image Note
TS28: spleen B cell Absent S3C B220 spleen
Specimen S3C CD23 thymus: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Fcer2a (assay MGI:7294417).
Structure Cell Type Level Pattern Image Note
TS28: thymus B cell Absent S3C CD23 thymus
Specimen S3C CD23 lymph node: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Fcer2a (assay MGI:7294417).
Structure Cell Type Level Pattern Image Note
TS28: lymph node B cell Absent S3C CD23 lymph node
Specimen S3C CD23 spleen: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Fcer2a (assay MGI:7294417).
Structure Cell Type Level Pattern Image Note
TS28: spleen B cell Absent S3C CD23 spleen
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04/16/2024
MGI 6.23 		The Jackson Laboratory