Rbfox3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:317003 Fregeac J, et al., Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits. Mol Autism. 2020 Mar 30;11(1):22
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7293279
Gene symbol:	Rbfox3
Gene name:	RNA binding protein, fox-1 homolog (C. elegans) 3

Antibody:	Anti-NeuN (EPR12763; ab177487)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

Specimen 2a +/+: embryonic day 14.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS22: cerebral cortex	neuron	Present	Regionally restricted	2a +/+	Expression in post-mitotic neurons.

Specimen 2a -/-: embryonic day 14.5; Mir146^tm1.1Bal/Mir146^tm1.1Bal (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS22: cerebral cortex	neuron	Present	Regionally restricted	2a -/-	The expressing cell layer is enlarged compared to controls.

Specimen S1a +/+: postnatal day 60 (more

)

Structure	Cell Type	Level	Pattern	Image
TS28: cortical layer II	neuron	Present	Regionally restricted	S1a +/+
TS28: cortical layer III	neuron	Present	Regionally restricted	S1a +/+
TS28: cortical layer IV	neuron	Present	Regionally restricted	S1a +/+
TS28: cortical layer V	neuron	Present	Regionally restricted	S1a +/+
TS28: cortical layer VI	neuron	Present	Regionally restricted	S1a +/+

Specimen S1a -/-: postnatal day 60; Mir146^tm1.1Bal/Mir146^tm1.1Bal (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cortical layer II	neuron	Present	Regionally restricted	S1a -/-	Expression in post-mitotic neurons in this mutant is the same as in wild-type.
TS28: cortical layer III	neuron	Present	Regionally restricted	S1a -/-	Expression in post-mitotic neurons in this mutant is the same as in wild-type.
TS28: cortical layer IV	neuron	Present	Regionally restricted	S1a -/-	Expression in post-mitotic neurons in this mutant is the same as in wild-type.
TS28: cortical layer V	neuron	Present	Regionally restricted	S1a -/-	Expression in post-mitotic neurons in this mutant is the same as in wild-type.
TS28: cortical layer VI	neuron	Present	Regionally restricted	S1a -/-	Expression in post-mitotic neurons in this mutant is the same as in wild-type.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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