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Gene Expression Data
Assay Details
Assay
Reference: J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7287515
Gene symbol: Pik3r2
Gene name: phosphoinositide-3-kinase regulatory subunit 2
Antibody: Anti-PI3 Kinase p85 (19H8) #4257
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: The antibody recognized both Pik3r1 MGI:7287514 and Pik3r2.
Results
Specimen 6E Sox9flox/+: embryonic day 14.5; Sox9tm2Crm/Sox9+ (more )
Note: Proximal humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 6E anti-Pik3r1/Pik3r2 Sox9flox/+ Expression was detected in round and flat proliferative chondrocytes.
Specimen 6E 11Prom-Cre; Sox9flox/flox: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant. Proximal humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 6E anti-Pik3r1/Pik3r2 11Prom-Cre; Sox9flox/flox There were no differences in expression levels in proliferative chondrocytes of the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory