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Gene Expression Data
Assay Details
Assay
Reference: J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7287512
Gene symbol: Pik3ca
Gene name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Antibody: Anti-Pik3ca (C73F8) #4249
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6E Sox9flox/+: embryonic day 14.5; Sox9tm2Crm/Sox9+ (more )
Note: Proximal humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 6E anti-Pik3ca Sox9flox/+ Expression was detected in round and flat proliferative chondrocytes.
Specimen 6E 11Prom-Cre; Sox9flox/flox: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant. Proximal humerus.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 6E anti-Pik3ca 11Prom-Cre; Sox9flox/flox Immunoreactivity decreased in proliferative chondrocytes that did not express Sox9 in the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory