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Gene Expression Data
Assay Details
Assay
Reference: J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7286342
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1E Sox9flox/+: embryonic day 13.5; Sox9tm2Crm/Sox9+ (more )
Structure Cell Type Level Pattern Image Note
TS21: humerus cartilage condensation chondrocyte Absent 1E anti-cleaved caspase-3 Sox9flox/+
Specimen 1E 11Enh-Cre; Sox9flox/flox: embryonic day 13.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)1Ntsu/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS21: humerus cartilage condensation chondrocyte Present Regionally restricted 1E anti-cleaved caspase-3 11Enh-Cre; Sox9flox/flox Cleaved Casp3 was detected in chondrocytes in the epiphyseal region in the disorganized cartilage in the humerus of the conditional mutant.
Specimen 3E Sox9flox/+: embryonic day 14.5; Sox9tm2Crm/Sox9+ (more )
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Absent 3E Anti-cleaved caspase-3 Sox9flox/+
Specimen 3E 11Prom-Cre; Sox9flox/flox: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: humerus cartilage condensation chondrocyte Present Regionally restricted 3E Anti-cleaved caspase-3 11Prom-Cre; Sox9flox/flox Significant apoptosis associated with the expression of cleaved Casp3 was detected in the zone of terminally mature chondrocytes.
Specimen S2A Sox9flox/+: embryonic day 12.5; Sox9tm2Crm/Sox9+ (more )
Structure Cell Type Level Pattern Image Note
TS20: humerus pre-cartilage condensation chondrocyte Absent S2A anti-cleaved caspase-3 Sox9flox/+
Specimen S2A 11Enh-Cre; Sox9flox/flox: embryonic day 12.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)1Ntsu/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: humerus pre-cartilage condensation chondrocyte Absent S2A anti-cleaved caspase-3 11Enh-Cre;Sox9flox/flox
Specimen S4B Sox9flox/+: embryonic day 13.5; Sox9tm2Crm/Sox9+ (more )
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Absent S4B Anti-cleaved caspase-3 Sox9flox/+
Specimen S4B 11Prom-Cre; Sox9flox/flox: embryonic day 13.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Absent S4B Anti-cleaved caspase-3 11Prom-Cre;Sox9flox/flox
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory