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Gene Expression Data
Assay Details
Assay
Reference: J:120296 Fitzgerald ML, et al., ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res. 2007 Mar;48(3):621-32
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7281886
Gene symbol: Sftpb
Gene name: surfactant associated protein B
Antibody: anti-SP-B
Detection system: Secondary antibody coupled to alkaline phosphatase
Results
Specimen S3A Abca3+/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung Present Regionally restricted S3A Abca3+/+

Specimen S3A Abca3-/-: embryonic day 18.5; Abca3tm1Frm/Abca3tm1Frm (more )
Structure Level Pattern Image Note
TS26: lung Weak Regionally restricted S3A Abca3-/- Dramatically less expression of mature SP-B in airspaces. Intracellular expression largely unnchanged compared with wildtype.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory