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Gene Expression Data
Assay Details
Assay
Reference: J:278471 Nakanishi H, et al., Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. Sci Rep. 2018 Aug 14;8(1):12125
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7266321
Gene symbol: Kcnma1
Gene name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Antibody: anti-KCNMA1 (P8357)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8B P16 Tmc1 +/+: postnatal day 16 (more )
Note: Double labeled: green - Kcnma1; red - Pvalb (assay MGI:7266317).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear inner hair cell Present Punctate 8B P16 Tmc1 +/+ Punctate expression at neck of inner hair cells in apical cochlear turn.
Specimen 8B P16 Tmc1 delta/delta: postnatal day 16; Tmc1tm1.1Ajg/Tmc1tm1.1Ajg (more )
Note: Double labeled: green - Kcnma1; red - Pvalb (assay MGI:7266317).
Structure Level Pattern Image Note
TS28: cochlea Absent 8B P16 Tmc1 delta/delta
Specimen 8B P25 Tmc1 +/+: postnatal day 25 (more )
Note: Double labeled: green - Kcnma1; red - Pvalb (assay MGI:7266317).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear inner hair cell Present Punctate 8B P25 Tmc1 +/+ Punctate expression at neck of inner hair cells in apical cochlear turn.
Specimen 8B P25 Tmc1 delta/delta: postnatal day 25; Tmc1tm1.1Ajg/Tmc1tm1.1Ajg (more )
Note: Double labeled: green - Kcnma1; red - Pvalb (assay MGI:7266317).
Structure Level Pattern Image Note
TS28: cochlea Absent 8B P25 Tmc1 delta/delta
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory