Gene Expression Data
Assay Details
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Assay
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Reference:
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J:322658
Calpena E, et al., Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders. J Med Genet. 2022 Feb;59(2):165-169
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:7261174
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Gene symbol:
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Six1
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Gene name:
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sine oculis-related homeobox 1
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Reporter:
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lacZ
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Direct Detection
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Results
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Specimen
1E:
embryonic day 18.5; Six1tm1Mair/Six1 +
(more  )
Specimen
1E:
(close  )
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Genetic Background:
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involves: 129S2/SvPas
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Mutant Allele(s):
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Six1tm1Mair/Six1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: brain dura mater |
Present |
Regionally restricted |
1E
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Expression in a layer basal to growing bones, likely corresponding to dura mater.
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| TS26: parietal bone |
Absent |
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1E
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No significant expression in osteogenic fronts.
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Specimen
1F:
embryonic day 18.5; Six1tm1Mair/Six1 +
(more )
Specimen
1F:
(close )
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Genetic Background:
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involves: 129S2/SvPas
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Mutant Allele(s):
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Six1tm1Mair/Six1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: sagittal suture |
Present |
Regionally restricted |
1F
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Expression extending into mesenchyme of future sagital suture.
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Specimen
S2B:
embryonic day 18.5; Six1tm1Mair/Six1 +
(more )
Specimen
S2B:
(close )
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Genetic Background:
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involves: 129S2/SvPas
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Mutant Allele(s):
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Six1tm1Mair/Six1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: frontal bone |
Absent |
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S2B
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No significant expression in osteogenic fronts.
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Specimen
S2C:
embryonic day 18.5; Six1tm1Mair/Six1 +
(more )
Specimen
S2C:
(close )
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Genetic Background:
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involves: 129S2/SvPas
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Mutant Allele(s):
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Six1tm1Mair/Six1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: coronal suture |
Absent |
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S2C
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No significant expression mid-sutural mesenchyme of coronal sutures
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Analysis Tools
