Gene Expression Data
Assay Details
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Assay
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Reference:
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J:308673
Company V, et al., Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons. Front Cell Dev Biol. 2021;9:682067
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7259912
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Gene symbol:
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Dcc
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Gene name:
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DCC netrin 1 receptor
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Results
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Specimen
2B:
embryonic day 13.5
(more  )
Specimen
2B:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: midbrain |
Present |
Regionally restricted |
2B
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Expressed in the medial habenular axons of the fasciculus retroflexus in the pial surface.
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Specimen
2D:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Gli2tm1Alj/Gli2tm1Alj
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: midbrain |
Ambiguous |
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2D
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The medial habenular axons of the fasciculus retroflexus were non-detectable as a compact superficial tract.
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Specimen
2F:
embryonic day 18.5
(more )
Specimen
2F:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: fasciculus retroflexus |
Present |
Regionally restricted |
2F
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Expressed in the medial habenular axons of the fasciculus retroflexus in the pial surface.
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Specimen
2H:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Gli2tm1Alj/Gli2tm1Alj
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: fasciculus retroflexus |
Present |
Regionally restricted |
2H
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The medial habenular axons of the fasciculus retroflexus was misoriented and crosses the midline in an abnormal position, far away from the superficial side of the midbrain.
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Specimen
2I:
embryonic day 18.5
(more )
Specimen
2I:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: fasciculus retroflexus |
Present |
Regionally restricted |
2I
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Expressed in the medial habenular axons of the fasciculus retroflexus, in all its length, from the habenula into rhombomere 1.
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Specimen
2J:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Gli2tm1Alj/Gli2tm1Alj
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: fasciculus retroflexus |
Present |
Regionally restricted |
2J
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Abnormal rostral bending into the hypothalamic territory was seen.
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Specimen
7A:
embryonic day 16.5
(more )
Specimen
7A:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: fasciculus retroflexus |
Present |
Regionally restricted |
7A
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Expressed in the medial habenular axons of the fasciculus retroflexus.
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Specimen
7B:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: fasciculus retroflexus |
Present |
Regionally restricted |
7B
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Expressed in the medial habenular axons of the fasciculus retroflexus, which displayed an abnormal trajectory. A bunch of these fibers followed the normal path until the basal plate. At that point, they bended caudally toward caudal positions.
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Specimen
7D:
embryonic day 16.5
(more )
Specimen
7D:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: fasciculus retroflexus |
Present |
Regionally restricted |
7D
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Expressed in the medial habenular axons of the fasciculus retroflexus in the pial surface.
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Specimen
7F:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: fasciculus retroflexus |
Present |
Regionally restricted |
7F
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The medial habenular axons were defasciculated, unable to reach the pial surface underneath substantia nigra pars compacta and ventral tegmental area, and occupied a dorsal position.
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