Casp8tm1.1Gne
Targeted Allele Detail
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| Symbol: |
Casp8tm1.1Gne |
| Name: |
caspase 8; targeted mutation 1.1, Genentech |
| MGI ID: |
MGI:7259812 |
| Synonyms: |
Casp81xDA, Casp8D387A |
| Gene: |
Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
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| Alliance: |
Casp8tm1.1Gne page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:281456
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| Parent Cell Line: |
C2 (Nagy) (ES Cell)
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| Strain of Origin: |
C57BL/6NTac
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| Allele Type: |
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Targeted (Not Specified) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Aspartic acid codon 387 (GAT) in exon 9 was mutated to alanine (GCC) (p.D387A). The FRT site flanked neomycin selection gene cassette that was inserted into intron 9 was removed through subsequent flp-mediated recombination.
(J:281456)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Casp8 Mutation: |
45 strains or lines available
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| Original: |
J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431 |
| All: |
2 reference(s) |
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Analysis Tools
